Molecular Pathology Laboratory
                        Understanding disease
                                One signal at a time....

Al-Mulla
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     TESTS OFFERED  Breast
cancer		  Colorectal cancer  Ewing's sarcoma  Oligodendroglioma Cytogenetics    

Diagnostic Division

Colorectal cancer

 

  

 

Microsatellite instability

Colon cancer: Colorectal cancer is common . The Mediterranean/Eastern population is less susceptible to it. However, colorectal cancer affects younger people in our population. We believe this is a reflection of a genetic susceptibility, which  overwhelms the environmental causes such as alcohol consumption, diet etc. Our population is thus suited to identify the possible genetic cause.

We offer a high fidelity microsatellite instability tests based on allelotyping and  immunohistochemistry algorithms.   

   

 

 MLH1-MSH2-PMS2
Sequencing

 

 We offer exome and whole genome sequencing on colorectal cancers and saliva/blood DNA to identify somatic and germline mutations respectively.

We perform immunohistochemitry for MLH1, MSH2, PMS2 and MSH6

Our lab performs mlh1 and  msh2 sequencing as part of the European Molecular Genetics quality assurance program

We perform Ki-Ras mutation profiling on CRC to tailor therapy. Patients with Wild-type Ki-Ras are more suited for chemical intervention

  We offer GIST mutation profiling
   

 
  CRC Genetic profiling for metastatic signature
Agilent Human Genome CGH Microarray 244K
  • 236,000+ coding and noncoding human sequences represented
  • Probes annotated against NCBI Build 36 (UCSC hg18, March 2006)
  • 8.9 KB overall median probe spacing (7.4 KB in Refseq genes)
  • 0.5 μg total genomic DNA input requirement
  • 1 x 244K slide format printed using Agilent's 60-mer SurePrint technology
  • Cost: 300 K.D per slide (1 array)
 
   
 

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